Research Supporting the Heart Health Benefits of CoQ10

CoQ10, a naturally occurring antioxidant, is a vital component in the production of cellular energy within the mitochondria. Beyond its role in energy production, CoQ10 has been the focus of numerous studies investigating its potential benefits for heart health.

One notable area of research involves the use of CoQ10 in the management of heart failure. The Q-SYMBIO trial, conducted over the past decade, revealed encouraging results. Patients with moderate to severe heart failure who received CoQ10 supplementation in long term in addition to standard therapy experienced improvements in symptoms, exercise capacity, and a significant reduction in major adverse cardiovascular events[1][2][3].

Studies exploring the impact of CoQ10 on blood pressure have also garnered attention. While the effects may be modest, research suggests that CoQ10 supplementation could contribute to lower blood pressure, especially in individuals with hypertension. This finding adds another layer to the potential cardiovascular benefits of CoQ10.

As statin medications became a cornerstone in cholesterol management, concerns arose regarding their potential to deplete CoQ10 levels in the body. Research has investigated the use of CoQ10 supplementation to counteract this depletion, potentially mitigating side effects associated with statin use[4]. 

As such, CoQ10 supplementation is important to be considered for heart health, particularly for statin users.

The Two Forms of CoQ10: Ubiquinol Reigns Supreme for Bioavailability

Coenzyme Q10 (CoQ10) exists in two forms—oxidized and reduced, with ubiquinol being the fully reduced version. When it comes to biological absorption and potential clinical benefits, ubiquinol outshines its oxidized counterpart, demonstrating significantly higher bioavailability.[5]

In a randomized, double-blind trial assessing CoQ10 bioavailability, the reduced form (ubiquinol) showcased a faster absorption rate compared to oxidized Coenzyme Q10. The study revealed that total CoQ10 reached its peak plasma concentration in just 15.5 ± 19.6 hours after ubiquinol supplementation, significantly outperforming the 26.5 ± 25.8 hours required with oxidized Coenzyme Q10.[5]

Further supporting ubiquinol's superiority, another study comparing plasma CoQ10 levels found that ubiquinol supplementation led to significantly better increases in plasma CoQ10 and the CoQ10/cholesterol ratio when compared to oxidized CoQ10 supplementation. [6]

At Xtendlife, we include genuine ubiquinol in our products, the active form of CoQ10 which is far more effective than the oxidised form of ubiquinone. As the body easily recognizes ubiquinol, it is better utilized and less is needed for a significant effect.

By combining CoQ10 with New Zealand fish oil and GG, the two unique formulas make CoQ10 more bioavailable for the body to absorb, which enables the maximum benefits of CoQ10. 

References:

[1] https://pubmed.ncbi.nlm.nih.gov/30835327/
[2] https://www.sciencedirect.com/science/article/pii/S2213177914003369
[3] https://pubmed.ncbi.nlm.nih.gov/35644694/
[4] https://pubmed.ncbi.nlm.nih.gov/25375075/
[5] https://www.sciencedirect.com/science/article/pii/S175646460800011X
[6] https://pubmed.ncbi.nlm.nih.gov/27128225/