Serene Saffron

29 Reviews
A natural solution formulated to restore a sense of calmness and positive wellbeing.
  • Help manage stress and anxiety
  • Promote good mood and wellbeing
  • Encourage better sleep quality and energy
Learn More
$43.95 USD
30 Day Supply | Size: 60 Capsules

Free DHL Express Courier on orders over $125 (USA only). Find country specific shipping details here

Find Bliss and Say Goodbye to Burnout

Lacking energy? Get moody easily and feel you are losing control? Modern lifestyles are fast-paced and sometimes it can feel like there is nothing you can do to slow things down. Meet Serene Saffron, the natural solution to support a positive mood, healthy sleep and energy, helping you find your inner calm and bliss.

Stress Management

Stress Management

Balance the release of cortisol and the resultant stress response with ashwagandha and saffron, manage stress and burnout.

Sleep and Energy

Sleep and Energy

Enhancing saffron and vitamin B group which aid the body to a state of complete relaxation, inducing deep sleep with ease.

Cognitive Health

Cognitive Health

Support brain function, attention and nervous system with ashwagandha and L-Theanine.

Powerful Adaptogens Backed by Science

Formulated with two powerful adaptogens – Saffron and Ashwagandha, this product provides the best plant extracts you can find in the market that are backed by science to help you find the right balance.

“Over the past couple of years, we’ve seen increasing rates of stress, depression and problems with sleep. It’s having a real impact on lives and customers were reaching out to us for a natural solution that would help.”

“We believe Serene Saffron can get to the root of stress and feeling overwhelmed by helping you feel calm, but focused enough and energised enough to get through a day’s work. Think of it as a better way to boost your mood and find your happy place and a sense of wellbeing.

“ Dr. Amanda Wiggins, PhD.

The Most Potent Saffron - Safr’Inside™

The benefits of saffron come from many active compounds, including safranal, crocin, and picrocrocin, however, it’s Safromotivines - the synergistic action of more than 25 compounds which you need to know when selecting a saffron supplement.

Our Serene Saffron formula contains 30 mg of Safr’Inside™, it’s known as the purest and richest in active compounds, it provides the highest concentration in safranal (>0.2%) and Safromotivines (12%). Safranal is the most described saffron compound for its action on serotonin amplification. Safr’Inside™ provides 10 times more Safranal than other non-encapsulated saffron extracts1. (Analysis by U-HPLC).

This saffron extract is from 100% red stigmas, providing the richest concentration in saffron active metabolites. The effectiveness has been confirmed in consumer tests and clinical studies2 .

More than 50% of participants have experienced an improvement in sleep, and ¾ have perceived emotional balance improvement after 30 days of consumption of Safr'Inside™.

The Gold Standard Ashwagandha

Our Serene Saffron formula also contains a special patented form of Ashwagandha - KSM-66 Aswagandha®. This highly potent Aswagandha extract has been evaluated in 24 published “Gold Standard” clinical trials for the benefits of sleep, stress, anxiety and cognitive health. It’s the most bioavailable full-spectrum ashwagandha root extract on the market.

In a double-blind, placebo-controlled study in 20193 and 20204 , participants who received 300-600 mg/day of ashwagandha for over 10 weeks showed:

1. Significant improvement in sleep efficiency

2. Significant increase in sleep quality

3. Significant increase in mental alertness

4. Significant calming effects, reduced nervousness

Additional Ingredients



Aquamin® Elemental Magnesium (Highly bio-available).

Natural relaxant promoting balanced mood and restful sleep. Optimizing brain and nerve function.

Vitamin B6

Vitamin B6

Increasing melatonin production, better quality of sleep and feeling more refreshed on waking.

Vitamin B12

Vitamin B12

Essential for vegetarians and the senior age group. Promote mental health, sleep and overall health.



Manage anxiety and promote relaxation. Improve the quality of sleep.

The Science Behind Stress

How does the body react to stress? Can a natural supplement be effective?

These and many more questions are all answered in this new podcast from Ivor Cummins.

Ivor Cummins is part of the Xtend-Life research and development team. He continues his research on the root causes of modern chronic disease.

Learn More About how to Maintain Mental Health

For those people who would like to get a better understanding of Serene Saffron and the rationale behind it our Chief Research Scientist Dr Amanda Wiggins PhD has prepared a series of blogs for your information.

Servings per bottle: 30
Daily serving: 2 capsules per day. 

For optimal benefits, take at least 30 minutes after a meal. Can be taken any time of the day or night. 

Combines well with our Total Balance products.

If you are pregnant, lactating or taking any medications, please consult your health practitioner before starting new supplements.

If you have any questions, please contact us at

Supplement Facts

Serving size: 2 Capsules
Servings per container: 30
Amount Per Serving   % DV*
Vitamin B6
(as Pyridoxal-5-Phosphate)
1.3 mg 76%
(as Calcium L-5-methyltetrahydrofolate)
150 mcg 38%
Vitamin B12
(as Cobamamide)
24 mcg 1000%
(from 545 mg Aquamin® Magnesium Hydroxide from sea water)
180 mg 43%
KSM-66 Ashwagandha® 600 mg **
L-Theanine 200 mg **
Safr'Inside™ Saffron Extract
(equivalent to 150 mgs of fresh Saffron)
30 mg **

Other Ingredients:Capsule (Hydroxypropylmethyl Cellulose, Water).

If you are pregnant, lactating or taking any medications, please consult your health practitioner before starting new supplements.


What are the benefits of Serene Saffron?

Helps manage feelings of stress and low mood and promote a sense of wellbeing. In addition, Serene Saffron may support a better night's sleep and may reduce stress-induced weight gain and overeating.

How long does it take for Serene Saffron to work?

Customers taking Serene Saffron may begin to notice an improvement in stress within one week. However, supplements can only be of assistance in conjunction with a healthy lifestyle so results may vary. For low mood, symptoms will be noticeably improved after two weeks. Maximum benefit will be experienced after several months.

Can I take my medication while taking Serene Saffron?

If you are taking medication for your thyroid, do not take Serene Saffron as taking Ashwagandha may increase thyroid hormone levels in some people.

If you are taking any other medication, please consult your healthcare practitioner before starting Serene Saffron.

Once approved, ensure a 2-3 hour gap between prescription medication and supplements.

Are there any side effects?

Some people may experience mild side effects such as gastrointestinal upset, headache or sleepiness. There are no serious side effects associated with any of the ingredients in Serene Saffron.

What time of day should I take Serene Saffron?

In general, you can take Serene Saffron any time of the day or night. It comes down to personal preference.

Should I take Serene Saffron with or without food?

It is recommended to take Serene Saffron 30 minutes after a meal for optimal absorption and digestive comfort.

Can I take more than the recommended dose?

This product is formulated to provide optimal efficacy based on clinical studies. The safety of larger doses is not known, therefore it is not recommended to take more than the daily dose.

Can I take Serene Saffron alongside Total Balance?

Yes, absolutely! This product has been designed to be either a standalone supplement or to be taken alongside Total Balance.

Can I give Serene Saffron to children or pets?

This product is not suitable for those under 18 years. Not suitable for pets.

Can I take Serene Saffron if I'm pregnant?

This product is not suitable during pregnancy.

Can I take Serene Saffron if I'm breastfeeding?

If you are breastfeeding, consult your healthcare practitioner before taking this product.

Is Serene Saffron suitable for vegans or vegetarians?

Yes, it is suitable for both vegetarians and vegans.

Does this product contain any allergens?

No, it does not contain any allergens.

Can I drink alcohol with this supplement?

Avoid alcohol or products that cause drowsiness with Serene Saffron.

Customer Reviews
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Filter Reviews:
    Jessica H.
    United States United States

    Works well for me

    This works well for me! It took about 7 days, but I have seen a difference and I will keep taking it.

    Darcy C.
    United States United States

    Truly helped my anxiety!!

    I tried Serene Saffron reluctantly and am so glad I did! I get anxiety that is debilitating at times. Taking this everyday has helped me lessen my anxiety way more than the other 10 products I have tried on the market. If you have anxiety that is taking you away from your normal life, believe me-This Works!! It has given me my life back. Thank you, Xtendlife, for this product!

    A Xtend-Life Group Limited Customer
    Denise M.
    United States United States

    Has helped me tremendously

    I've tried all kinds of supplements for mood balance along with my usually healthy eating and exercise and must say I feel this is finally something that seems to give me relief from my lows. I still get a little cranky but don't have the dark cloud that usually overtakes me for weeks or a month at a time. Maybe it's a placebo affect but this is the best balance I've felt in a long time. Thank you!

    Darcy C.
    United States United States

    Has helped my anxiety!

    I have anxiety that is pretty debilitating at times. When I started Serene Saffron, I noticed a diff within the first few days. Less anxious feelings, less over thinking, better sleep. I take it everyday now and feel so much better! Thank you, Xtendlife for making this great supplement!!

    Lydia N.
    United States United States

    Serene Saffron

    This is my second bottle, in my opinion, it's a great supplement for few different aspects... The ingredients, and quality as well... As a consumer and a dedicated person to research about health, supplements, nutrition as a life style... I learned that we all need to take the necessary time to adjust and make the right changes in order to proof the effectiveness of any plement, and of course, monitor our bodies and our own health's issues that we may be encountering before. From TN. USA

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