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Geranylgeraniol (GG) is the raw fuel for some of our bodies most important processes. Very few people other than some scientists and well-informed Doctors are aware of this substance.
It plays a vital role in the mevalonate metabolic pathway– the series of chemical reactions in our bodies to support:
As we age, levels of GG in our bodies diminish, and this can be a factor in age-related conditions. This process is accelerated if you are taking a statin or one of the bisphosphonate medications.
This is because these medications cause ‘roadblocks’ in this mevalonate pathway. Statins are effective in lowering cholesterol because the ‘roadblock’ restricts the enzymes that the liver needs to produce cholesterol (note: 80% of the cholesterol in our bodies is produced by our livers, only 20% is from diet).
BUT… they also cut off the supply of the ‘fuel’ that our bodies need to produce GG, and this is serious because only a small portion of the GG that our bodies need can be obtained by diet. We are reliant on our own bodies to manufacture it.
When we are deficient in GG, all sorts of health issues may stem from it and is a major factor in the common side effects found by those people who are on statin medications. The side effects are primarily due to the reduction in Protein Prenylation that keeps the muscles healthy, and the lack of this process may lead to muscle pain.
The diagram below helps illustrate this:
Many scientists and health professionals are aware of the problems resulting from a GG deficiency in both ‘healthy’ aging people and those on medications, but there was no easy solution.
It has been well established by many researchers worldwide over many years in cellular experiments that taking GG exogenously (orally) would restore natural levels of GG in the body and negate the ill effects of its deficiency due to age or medications. The challenge was to find a suitable natural source of GG. GG is present in nature as part of some plants but only in small quantities.
Dr. Barrie Tan, PhD American Scientist and Researcher, solved the problem of how to replenish GG in the body naturally. Dr. Tan is also a world expert on vitamin E and Tocotrienols.
He has multiple PhD's and has spent his career travelling and searching out solutions to issues that affect the health of our bodies. He was a pioneer in the field of vitamin E and Tocotrienol research and uncovered a lot of misconceptions in the area of vitamin E, which everyone should be aware of.
He is the author of an enlightening and entertaining book called 'The Truth about Vitamin E', which we would urge everyone to read. We can provide you with a free copy by clicking here.
After more than 10 years of research on GG, vitamin E and Tocotrienols, Dr. Tan perfected a technique of naturally extracting GG from the Annatto seeds harvested sustainably from the Amazon rain forest.
He was already very familiar with this plant after researching possible natural sources from the Amazon rain forest over many years. He developed the means of extracting Tocotrienols from the annatto seed and ultimately managed to perfect the technology to extract the GG as well... without the use of solvents or other chemicals.
This enabled us to produce the product GG PURE and make it available to our customers.
The below image illustrates the objective of GG PURE, which is to 'top up' and help support your GG at normal healthy levels.
NOTE: Because it is 'downstream' of the part of the pathway that statins use to inhibit the production of cholesterol, it has no negative impact on the efficacy of the statin medication.
Ivor Cummins, who is on our scientific board, recently interviewed Dr. Barrie Tan to talk about GG. The video is quite technical but has a good explanation of how GG can benefit you.
If you are on either of the medications referred to, we would suggest that you talk to your Doctor about adding GG PURE to your regimen. It has no negative impact on your medications.
If you are free of medications but over 45 years of age, it would be a good idea to add it to your normal supplement regimen, even if you are taking Total Balance or any of our supplements. GG PURE is complimentary to all of them and has a different mechanism of action, and will support your overall health objectives.
We have prepared a document for our customers who wish to dig deeper into the technicalities of this product or who wish to give a copy to their Doctor. Click on the image to download.
CAO, P. et al. Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. FASEB Journal. Sep 2009;23(9)2844-2854.
JASKIEWICZ, A. et al. Geranylgeraniol Prevent Statin-Dependent Myotoxicity in C2C12 Muscle Cells through RAP1 GTPase Prenylation and Cytoprotective Autophagy. Oxidative Medicine and Cellular Longevity Volume 2018, Article ID 6463807, 22 pages.
JASKIEWICZ, A. et al. Diverse Action of Selected Statins on Skeletal Muscle Cells—An Attempt to Explain the Protective E_ect of Geranylgeraniol (GGOH) in Statin-Associated Myopathy (SAM). Journal of Clinical Medicine. 2019, 8, 694; doi:10.3390/jcm8050694.
CAMPIA, I. et al. Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis. British Journal of Pharmacology. Dec 2009;158(7);1777-1786.
CORSINI, A. et al. Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. Artherosclerosis. Jun 1993;101(11):117-125.
VOGT, A. et al. Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. Oncogene Nov 7 1996;13(9):1991-1999.
CRICK, D. C. et al. Novel Salvage Pathway Utilizing Farnesol and Geranylgeraniol for Protein Isoprenylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 237, 483–487 (1997) ARTICLE NO. RC977145
KALEN, A. et al. Age-Related changes in the lipid compositions of rat and human tissues. Lipids, 1989; 24 (7) 579-584.
RRODICK, T. C. et al. Potential role of coenzyme Q10 in health and disease conditions. Nutrition and Dietary Supplements 2018:10 1–11
STOFFEL, W. et al. Synthese der K Vitamine and Ubichionone. Agnew Chem. 1960;72(17);627-627.
HIROTA, Y. et al. Functional Characterization of the Vitamin K2 Biosynthetic Enzyme UBIAD1. PLoS ONE 10(4): e0125737. doi:10.1371/journal.pone.0125737
OKUYAMA, H. et al. Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Review of Clinical Pharmacology. 2015 8:2, 189-199, DOI: 10.1586/17512433.2015.1011125
HIROTA, Y. et al. Functional Characterization of the Vitamin K2 Biosynthetic Enzyme UBIAD1. PLoS ONE 10(4): e0125737. doi:10.1371/journal.pone.0125737
OKAMURA, K. et al. Serum total and free testosterone level of Japanese men: a population-based study. International Journal of Urology (2005) 12, 810–814.
HO, H-J. et al. Geranylgeraniol enhances testosterone production via the cAMP/protein kinase A pathway in testis-derived I-10 tumor cells. Bioscience, Biotechnology, and Biochemistry, 2016. Vol. 80, No. 4, 791–797
HO,H-J. et al. A novel function of geranylgeraniol in regulating testosterone production. Bioscience, Biotechnology, and Biochemistry, 2018 https://doi.org/10.1080/09168451.2017.1415129
Morocco
United States United StatesIt was good. I feel better and the claims that it counteracts statins seems to be true.
United StatesI am glad to take this product to offset possible side effects of low co q10 due to statins. Highly recommend this product!
United StatesJust started the supplement a few weeks ago, so I have to wait longer to see results. May I say that dealing with the company was a pleasure. Ordering procedure was fast, efficient, and very pleasant. Delivery was prompt.
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