Serene Saffron

27 reviews
A natural solution formulated to restore a sense of calmness and positive wellbeing.
  • Help manage stress and anxiety
  • Regulate mood
  • Support weight management, libido and sleep
Learn More
$43.95 USD
30 Day Supply | Size: 60 Capsules

Free DHL Express Courier on orders over $125 (USA only). Find country specific shipping details here


The Path From Stress to Serenity

Dr. Amanda Wiggins, PhD, explains how you can find your new happy place with Serene Saffron.

“Over the past couple of years, we’ve seen increasing rates of stress, depression and problems with sleep. It’s having a real impact on lives and customers were reaching out to us for a natural solution that would help.”

As a PhD in neurology and Chief Research Scientist at Xtend-Life, Amanda was ideally placed to work with Warren to find a solution.

The combination of her research experience and the 20 years+ of Xtend-Life’s experience in manufacturing complex and sophisticated supplements facilities at Xtend-Life meant it was possible to develop a supplement that really worked and was supported by strong science.

“We believe Serene Saffron can get to the root of stress and feeling overwhelmed by helping you feel calm, but focused enough and energised enough to get through a day’s work. Think of it as a better way to boost your mood and find your happy place and a sense of wellbeing. “

What can I Expect with Serene Saffron?

Each of the ingredients in Serene Saffron works in a different way to help your body combat feelings of stress, feelings of being overwhelmed and low mood. Over time, you can expect an improved sense of wellbeing.

That said, it’s important to understand that no supplement is going to make you superhuman.

Sadly, we’re living in a time where, for many people, stress and anxiety are the new normal, so the goal for many people is to get back to the “old normal” – back to the real you.

And in a time of stress, being normal - whether it’s a skip in your step, smiling more or just looking forward to getting out and seeing people again – sometimes needs a little help.

Week 1

The special form of saffron that we have selected in Serene Saffron has been clinically proven to start improving your mood in as little as 1 week.

At the same time, the L-Theanine gets to work immediately to deliver a feeling of relaxed alertness meaning you can concentrate for longer without the jittery effects of caffeine.

Week 2

After about 2 weeks, you should start feeling the effects of the special KSM-66 form of Ashwagandha with lower levels of stress and anxiety due to a reduction in the stress hormone… cortisol.

The saffron continues to improve mood.

Continue taking Serene Saffronas part ofyour daily routine.

Long Term

After a month of taking the ingredients in Serene Saffron each day, you should start to feel an improved quality of life and well being. Studies show the effects of saffron continue to build with improved mood flowing through to a better sense of wellbeing which leads on to other health benefits. Ashwagandha becomes more effective at relieving stress over time, while L-Theanine brings relaxed alertness during the day. Together the ingredients combine to deliver more restful sleep.

Break the Stress Cycle Naturally

When Warren Matthews saw the increasing number of people looking for relief from stress and feeling overwhelmed, he knew it was a challenge he couldn't refuse. After all, as the founder of Xtend-Life and a wellbeing health specialist who has helped hundreds of thousands of people solve their health over the last twenty years, he was in a unique position to help.

My vision for Xtend-Life was as a unique company that would develop and manufacture solutions for people looking to find a better way to improve their health.

When I saw the changes in people I knew, people who had previously been outgoing, sociable, being increasingly isolated, I wanted to reach out and help.

I worked with our team to produce a formula that will support people in decreasing stress and improving mood and aims to deliver all the healthy side benefits that an improved sense of wellbeing can provide.

We had two main aims - make it natural, and find the most effective ingredients.

With Serene Saffron, I believe we've done this.

Warren Matthews, Aged 74
Founder of Xtend-Life

Key Ingredients

There are seven ingredients in Serene Saffron four of which are co-factors to support the efficacy of the three main ingredients. Serene Saffron brings together a rich history using natural remedies dating back thousands of years across Asian and Persian cultures. Two of these ingredients have had their efficacy enhanced through modern scientific extraction processes. As with all Xtend-Life products we look at ways to also synergistically combine the best ingredients to multiply their effect. It is often possible to make 1 + 1= 3. This is what we believe we have achieved with the strategic combination of these key ingredients.


Ashwagandha has been traditionally known for centuries to help reduce stress, anxiety, cortisol levels and stress-related food cravings.

We selected a special patented form of Ashwagandha referred to as KSM-66, which is extracted from the root, not the leaves which are less potent. This is the highest concentration full-spectrum extract that we could source and has been validated by independent trials.


Saffron is an ancient traditional anti-stress herb that has been clinically proven to show a 60% reduction in the feeling of being stressed or nervous often.

We use a special patented extract called Safr’Inside from the south of France. It only uses one part of the saffron flower… the redder part of saffron stigmas which is the richest in the active compound (Safromotivines). This is the part that gives saffron its special properties.


L-Theanine has been taken for thousands of years to improve concentration, focus and relaxation.

It does this by boosting levels of brain serotonin (responsible for mood and happiness) and dopamine (responsible for reward and motivation). The result is to help increase alertness and performance under stress.

The Cycle of Stress and Anxiety

Stress and low mood feed on each other, creating a cycle that can spiral out of control. Add to this the side effects of stress and low mood and the effect is multiplied. Anxiety and stress can even cause you to become physically ill – you tend to lose sleep and have digestion problems (the energy usually used for your gut is instead sent to manage the higher levels of cortisol in your blood).


Depression and anxiety soars

New report reveals record number suffering from mental health issues.

Herbal relief relieves stress symptoms

Multiple studies prove the benefits of saffron and ashwagandha in combating stress, mood and low energy.

Xtend-Life Release Serene Saffron

Company founder explains how breakthrough formula with aims to support mental wellbeing.

The last two years have seen an endless news cycle of doom and gloom which has helped feed an increasing spiral of mental health distress. Add in the political, environmental and technological changes, and the new world of regulations that have people reporting feeling increasing amounts of social isolation, and stress and anxiety has become a normal part of modern life.

But though it’s become more normal, that doesn’t mean it’s easy to deal with. And for many people, it’s only getting worse.

The last two years have seen an endless news cycle of doom and gloom which has helped feed an increasing spiral of mental health distress. Add in the political, environmental and technological changes, and the new world of regulations that have people reporting feeling increasing amounts of social isolation, and stress and anxiety has become a normal part of modern life.

But though it’s become more normal, that doesn’t mean it’s easy to deal with. And for many people, it’s only getting worse.

Tips for Mental Health

There is no single cure for feelings of stress, being overwhelmed and low mood. As with most things related to health, the best cure is to take a broad look across your physical, mental, emotional and dietary health. So while supplements can certainly help, here are some easy tips to improve your mental well being.

Stay connected – reach out to friends or family to share what you’re thinking and feeling, and to stay in touch with what they’re doing. Maybe even combine with a walk or other exercise.

Exercise – there are proven benefits to exercise from heart health to mental health. Getting outside can get you vitamin D from the sun and it can even help with sleep.

Sleep – our brain needs to rest, get into regular sleep patterns and give yourself time to wind down before you go to sleep, avoid caffeine and screens at the end of the day.

Learn More About how to Maintain Mental Health

For those people who would like to get a better understanding of Serene Saffron and the rationale behind it our Chief Research Scientist Dr Amanda Wiggins PhD has prepared a series of blogs for your information.

The Science Behind Stress

How does the body react to stress? Can a natural supplement be effective?

These and many more questions are all answered in this new podcast from Ivor Cummins.

Ivor Cummins is part of the Xtend-Life research and development team. He continues his research on the root causes of modern chronic disease.


A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). Indian journal of psychological medicine, 34(3), 255.

Jackson, P.A., Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial. Front. Nutr., 01 February 2021.

Monchaux De Oliveira, C. et al., Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission. Nutrients 2021, 13, 904.

Hausenblas, H. A., Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. J Integr Med. 2013 November ; 11(6): 377–383

White, P. T., et al. Natural Withanolides in the Treatment of Chronic Diseases. Adv Exp Med Biol.928:329-373; 2016.

Choudhary, D. et. al. Body Weight Management in Adults Under Chronic Stress Through Treatment with Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. Journal of Evidence-Based Complementary & Alternative Medicine 1-11; 2016.

Chandrasekhar, K., et al. A Prospective, Randomized Double-Blind, Placebo Controlled Study of Safety and Efficacy of a High Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. Indian Journal of Psychological Medicine. Jul - Sep 2012. Vol 34. Issue 3.

Kelgane, S. B., Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study. Cureus. 2020 Feb; 12(2): e7083.

 Hidese, S., et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients11, 2362; 2019.

Hidese, S., et al. Effects of chronic L-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatrica 2017.

Ota, M., et al. Effect of L-theanine on sensorimotor gating in healthy human subjects. Psychiatry and Clinical Neurosciences; 68: 337–343; 2014.

Baba, Y., et al. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study. J Med Food 24 (4), 333–341; 2021.

Servings per bottle: 30
Daily serving: 2 capsules per day. 

For optimal benefits, take at least 30 minutes after a meal. Can be taken any time of the day or night. 

Combines well with our Total Balance products.

If you are pregnant, lactating or taking any medications, please consult your health practitioner before starting new supplements.

If you have any questions, please contact us at

Supplement Facts

Serving size: 2 Capsules
Servings per container: 30
Amount Per Serving   % DV*
Vitamin B6
(as Pyridoxal-5-Phosphate)
1.3 mg 76%
(as Calcium L-5-methyltetrahydrofolate)
150 mcg 38%
Vitamin B12
(as Cobamamide)
24 mcg 1000%
(from 545 mg Aquamin® Magnesium Hydroxide from sea water)
180 mg 43%
KSM-66 Ashwagandha® 600 mg **
L-Theanine 200 mg **
Safr'Inside™ Saffron Extract
(equivalent to 150 mgs of fresh Saffron)
30 mg **

Other ingredients:Capsule (Hydroxypropylmethyl Cellulose, Water).

If you are pregnant, lactating or taking any medications, please consult your health practitioner before starting new supplements.


What are the benefits of Serene Saffron?

Helps manage feelings of stress and low mood and promote a sense of wellbeing. In addition, Serene Saffron may support a better night's sleep and may reduce stress-induced weight gain and overeating.

How long does it take for Serene Saffron to work?

Customers taking Serene Saffron may begin to notice an improvement in stress within one week. However, supplements can only be of assistance in conjunction with a healthy lifestyle so results may vary. For low mood, symptoms will be noticeably improved after two weeks. Maximum benefit will be experienced after several months.

Can I take my medication while taking Serene Saffron?

If you are taking medication for your thyroid, do not take Serene Saffron as taking Ashwagandha may increase thyroid hormone levels in some people.

If you are taking any other medication, please consult your healthcare practitioner before starting Serene Saffron.

Once approved, ensure a 2-3 hour gap between prescription medication and supplements.

Are there any side effects?

Some people may experience mild side effects such as gastrointestinal upset, headache or sleepiness. There are no serious side effects associated with any of the ingredients in Serene Saffron.

What time of day should I take Serene Saffron?

In general, you can take Serene Saffron any time of the day or night. It comes down to personal preference.

Should I take Serene Saffron with or without food?

It is recommended to take Serene Saffron 30 minutes after a meal for optimal absorption and digestive comfort.

Can I take more than the recommended dose?

This product is formulated to provide optimal efficacy based on clinical studies. The safety of larger doses is not known, therefore it is not recommended to take more than the daily dose.

Can I take Serene Saffron alongside Total Balance?

Yes, absolutely! This product has been designed to be either a standalone supplement or to be taken alongside Total Balance.

Can I give Serene Saffron to children or pets?

This product is not suitable for those under 18 years. Not suitable for pets.

Can I take Serene Saffron if I'm pregnant?

This product is not suitable during pregnancy.

Can I take Serene Saffron if I'm breastfeeding?

If you are breastfeeding, consult your healthcare practitioner before taking this product.

Is Serene Saffron suitable for vegans or vegetarians?

Yes, it is suitable for both vegetarians and vegans.

Does this product contain any allergens?

No, it does not contain any allergens.

Can I drink alcohol with this supplement?

Avoid alcohol or products that cause drowsiness with Serene Saffron.

Customer Reviews
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Filter Reviews:
    A Xtend-Life Group Limited Customer
    Denise M.
    United States United States

    Has helped me tremendously

    I've tried all kinds of supplements for mood balance along with my usually healthy eating and exercise and must say I feel this is finally something that seems to give me relief from my lows. I still get a little cranky but don't have the dark cloud that usually overtakes me for weeks or a month at a time. Maybe it's a placebo affect but this is the best balance I've felt in a long time. Thank you!

    Darcy C.
    United States United States

    Has helped my anxiety!

    I have anxiety that is pretty debilitating at times. When I started Serene Saffron, I noticed a diff within the first few days. Less anxious feelings, less over thinking, better sleep. I take it everyday now and feel so much better! Thank you, Xtendlife for making this great supplement!!

    Lydia N.
    United States United States

    Serene Saffron

    This is my second bottle, in my opinion, it's a great supplement for few different aspects... The ingredients, and quality as well... As a consumer and a dedicated person to research about health, supplements, nutrition as a life style... I learned that we all need to take the necessary time to adjust and make the right changes in order to proof the effectiveness of any plement, and of course, monitor our bodies and our own health's issues that we may be encountering before. From TN. USA

    Tracy C.
    United States United States

    Excellent Product

    Great success with Serene Safforn. Gives me a calming feeling through out the day.

    Craig K.
    United States United States

    Serene Saffron?

    The jury is still out, I haven't noticed anything different, since taking it.

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