Orotates are mineral salts of orotic acid, used by plants and animals
to make DNA and RNA. Orotate salts, being neutrally charged, pass
easily through cell membranes. In effect, orotate ferries the mineral
atoms into cells and tissues, producing higher concentrations.
Zinc orotate is used to treat symptoms of zinc deficiency:
osteoporosis, hypogonadism, low testosterone levels, cardiovascular
disease, diabetes, atrophy of the thymus, low white blood cell counts,
and lowered immunity.
Zinc also plays a vital role in immune function, where deficiency is
associated with atrophy of the thymus, reduction in white blood cell
counts, and increased susceptibility to infection.
Zinc deficiency is known to be associated with an increased prevalence
of coronary artery disease as well as diabetes, and with several
associated risk factors including hypertension, hypertriglyceridemia,
and insulin resistance (syndrome X).