Magnesium trisilicate is a compound of magnesium oxide and silicon
dioxide with varying proportions of water. It occurs in nature as
meerschaum, pararepiolite, and repiolite. It is used mostly as a
gastric antacid. This is a good form for the body to accept this
combination in, as it is helpful and most absorbable to the digestive
system, and more easily used by the body, taking it into the
bloodstream to the skelaton where it is needed.
Greater magnesium intake is significantly related to higher bone
mineral density (BMD) in men and women, and silicon is a well known
essential mineral of good bone health.
Magnesium and Silicon
Journal of the American Geriatrics Society in Journal of the American Geriatrics
A higher intake of magnesium from food and supplements may keep bones
healthy as people age, according to results of a study in Journal of
the American Geriatrics Society which suggests that greater magnesium
intake is significantly related to higher bone mineral density (BMD) in
white men and women.
According to the paper, there was an approximate 2 percent increase in
whole-body BMD for every 100 milligram per day increase in magnesium.
"Higher magnesium intake through dietary change or supplementation may
provide an additional strategy for the prevention of osteoporosis,"
Osteoporotic fractures are a significant health problem in aging
adults, Dr. Kathryn M. Ryder, of the University of Tennessee, Memphis,
and colleagues note in their report.
Magnesium is a "lesser-studied" component of bone that may play a role in calcium metabolism and bone strength, they add.
Ryder's group examined magnesium intake from supplemental and dietary
sources in relation to BMD in a total of 2038 black and white subjects
between the ages of 70 and 79 years enrolled in the cross-sectional
Health, Aging, and Body Composition Study.
They used a semiquantitative food frequency questionnaire to assess
dietary intake of magnesium and standard tests to measure BMD.
Less than 26 percent of the study sample met the RDA for magnesium, the investigators report.
White and black women reported a similar intake of food magnesium, but
because of more frequent magnesium-containing supplement use, white
women had a higher total mean intake.
After multivariate adjustment, magnesium intake was positively associated with BMD in white, but not black, men and women.
The lack of an association in black men and women may be due to
differences in calcium regulation or in nutrient reporting, the
Dietary silicon intake is positively associated with bone
mineral density in men and premenopausal women of the Framingham
Jugdaohsingh R, Tucker KL, Qiao N, Cupples LA, Kiel DP, Powell JJ.
Gastrointestinal Laboratory, The Rayne Institute, St Thomas' Hospital, London, United Kingdom
The role of dietary silicon in bone health in humans is not known. In a
cross-sectional, population-based study (2847 participants),
associations between dietary silicon intake and BMD were investigated.
Dietary silicon correlated positively and significantly with BMD at all
hip sites in men and premenopausal women, but not in postmenopausal
women, suggesting that increased silicon intake is associated with
increased cortical BMD in these populations. INTRODUCTION: Osteoporosis
is a burgeoning health and economic issue. Agents that promote bone
formation are widely sought. Animal and cellular data suggest that the
orthosilicate anion (i.e., dietary silicon) is involved in bone
formation. The intake of silicon (Si, approximately 30 mg/day) is among
the highest for trace elements in humans, but its contribution to bone
health is not known. MATERIALS AND METHODS: In a cross-sectional,
population-based study, we examined the association between silicon
intake and bone mineral density (BMD) in 1251 men and 1596 pre- and
postmenopausal women in the Framingham Offspring cohort (age, 30-87
years) at four hip sites and lumbar spine, adjusting for all potential
confounding factors known to influence BMD and nutrient intake.
RESULTS: Silicon intake correlated positively with adjusted BMD at four
hip sites in men and premenopausal women, but not in postmenopausal
women. No significant association was observed at the lumbar spine in
any group. Categorical analysis by Si intake, or energy-adjusted Si
intake, supported these findings, and showed large differences in BMD
(up to 10%) between the highest (> 40 mg Si/day) and lowest (< 14
mg Si/day) quintiles of silicon intake. A significant association at
the lumbar spine in men was also observed. Further analyses indicated
that some of the effects seen for moderate consumption of alcoholic
beverages on BMD might be attributed to Si intake. CONCLUSIONS: These
findings suggest that higher dietary silicon intake in men and younger
women may have salutary effects on skeletal health, especially cortical
bone health, that has not been previously recognized. Confirmation of
these results is being sought in a longitudinal study and by assessment
of the influence of silicon intake on bone markers in this cohort.
PMID: 14969400 [PubMed - indexed for MEDLINE]
Silicon May Play Important Role in Bone Health: Presented at ASBMR
By Mike Fillon
NASHVILLE, TN -- September 27, 2005 -- Silicon, taken as
choline-stabilized orthosilicic acid (ch-OSA) supplementation, might
help improve bone health and type I collagen synthesis, according to
study results presented here on September 24th in a poster at the
American Society for Bone and Mineral Research (ASBMR) 27th Annual
Researchers investigated the effect of low dose silicon delivered as
ch-OSA on markers of bone turnover and bone mineral density (BMD)
during a 12-month, randomized, placebo-controlled trial. A total of 114
women with a mean age of 61 years and either osteopenia or osteoporosis
completed the study.
The subjects were divided into four groups all of which supplemented
their diet with 1000 mg of elemental calcium (CA) and 800 IU of vitamin
D3 daily, which, according to lead researcher, Tim D. Spector, MD,
FRCP, is the standard recommended dosages for osteopenia and
osteoporosis. This was the only medication taken by the subjects in the
placebo group. The three other groups also supplemented with either 3,
6, or 12 mg of elemental silicon as ch-OSA.
The researchers found that in all groups, there was wide variation in
the changes to bone markers at six and 12 months compared to baseline
so covariate analysis was used to adjust for baseline values.
Specifically, Dr. Spector, who is a consultant rheumatologist and
director of the Twin and Genetic Epidemiology Unit, at St. Thomas'
Hospital In London, UK, said there was an overall trend for ch-OSA to
confer some additional benefit to Ca/Vit D3 supplementation based onb
improvements towel-established markers of bone formation such as
Procollagen Type I N-terminal Propeptide (PINP), Bone Specific Alkaline
Phosphatase (BAP), and Osteocalcin. Dr. Spector said the benefits were
especially apparent when evaluating changes in PINP, the most sensitive
bone formation marker, and resulted in significant improvements after
12 months amongst the subjects in the six and 12 mg silicon groups.
The researchers found that spinal BMD did not change significantly.
However, subgroup analysis showed that subjects taking six mg of
silicon per day, and whose femur T score was less than –1 at the start
of the study, showed significant femoral neck BMD improvements.
"This study suggests that combined therapy of ch-OSA plus Ca/VIT D3 is
a safe, well tolerated treatment that has a potentially beneficial
effect on bone turnover, especially bone collagen, and possibly femoral
BMD, compared to CA/Vit D3 alone," said Dr. Spector