Magnesium oxide, or magnesia, is a white solid mineral that occurs
naturally as periclase and is a source of magnesium. Taking Magnesium
orally might prevent bone loss in postmenopausal osteoporosis.
Epidemiological research suggests that magnesium intake is related to
bone mineral density.
One study of postmenopausal women who were also taking oestrogen,
magnesium, plus calcium, and a multivitamin increased bone mass better
than oestrogen alone.
Although we normally use a citrate form of Magnesium, in Bone-Protec
we use an oxide form as this is the most compatible form of Magnesium
to go with Coral Calcium.
Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis
Stendig-Lindberg G, Tepper R, Leichter I.
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Since magnesium regulates calcium transport, and magnesium
replacement in magnesium-deficient postmenopausal patients resulted in
unexpected improvement in documented osteoporosis, we investigated the
effect of magnesium treatment on trabecular bone density in
postmenopausal osteoporosis. Thirty-one postmenopausal patients (mean
age +/- SD = 57.6 +/- 10.6 years), consecutively admitted to the Back
Rehabilitation Unit with musculoskeletal pain of non-malignant origin
and bone density values of < or = 1.19 g/cm3 (measured by Compton
Bone Densitometer), received two to six tablets daily of 125 mg each of
magnesium hydroxide (Magnesium Magma USP/; 'Mazor', Israel) for 6
months and two tablets for another 18 months in a 2 year, open,
controlled therapeutic trial. Twenty-three symptom-free postmenopausal
women (mean +/- SD = 61.2 +/- 6.2 years) whose bone density was
concurrently assessed at the same laboratory and who were found to have
osteoporosis but refused treatment, served as controls. No new
fractures occurred. Twenty-two patients (71 per cent) responded by a
1-8 per cent rise of bone density. The mean bone density of all treated
patients increased significantly after 1 year (P < 0.02) and
remained unchanged after 2 years (P > 0.05). The mean bone density
of the responders increased significantly both after one year (P <
0.001) and after 2 years (P < 0.02), while in untreated controls,
the mean bone density decreased significantly (P < 0.001). The
disparity between the initial mean bone density and bone density after
one year in all osteoporotic patients and in the responders differed
significantly from that of the controls.
A total dietary program emphasizing magnesium instead of
calcium. Effect on the mineral density of calcaneous bone in
postmenopausal women on hormonal therapy
Abraham GE, Grewal H.
Optimox, Inc., Torrance, CA.
The use of calcium supplementation for the management of primary
postmenopausal osteoporosis (PPMO) has increased significantly in the
past few years. A review of the published data does not support calcium
megadosing during postmenopause. Controlled studies showed no
significant effect of calcium intake on mineral density of trabecular
bone and a slight effect on cortical bone. Since PPMO is predominantly
due to demineralization of trabecular bone, there is no justification
for calcium megadosing in postmenopausal women. Soft tissue
calcification is a serious risk factor during calcium megadosing under
certain conditions. A total dietary program emphasizing magnesium
instead of calcium for the management of PPMO takes into account the
available data on the effects of magnesium, life-style and dietary
habits on bone integrity and PPMO. When this dietary program was tested
on 19 postmenopausal women on hormonal replacement therapy who were
compared to 7 control postmenopausal women, a significant increase in
mineral bone density of the calcaneous bone (BMD) was observed within
one year. Fifteen of the 19 women had had BMD below the spine fracture
threshold before treatment; within one year, only 7 of them still had
BMD values below that threshold.
Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women
Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP.
Jean Mayer US Department of Agriculture Human Nutrition Research
Center on Aging at Tufts University, Boston, MA 02111, USA.
BACKGROUND: Osteoporosis and related fractures will be growing
public health problems as the population ages. It is therefore of great
importance to identify modifiable risk factors. OBJECTIVE: We
investigated associations between dietary components contributing to an
alkaline environment (dietary potassium, magnesium, and fruit and
vegetables) and bone mineral density (BMD) in elderly subjects. DESIGN:
Dietary intake measures were associated with both cross-sectional
(baseline) and 4-y longitudinal change in BMD among surviving members
of the original cohort of the Framingham Heart Study. Dietary and
supplement intakes were assessed by food-frequency questionnaire, and
BMD was measured at 3 hip sites and 1 forearm site. RESULTS: Greater
potassium intake was significantly associated with greater BMD at all 4
sites for men and at 3 sites for women (P < 0.05). Magnesium intake
was associated with greater BMD at one hip site for both men and women
and in the forearm for men. Fruit and vegetable intake was associated
with BMD at 3 sites for men and 2 for women. Greater intakes of
potassium and magnesium were also each associated with less decline in
BMD at 2 hip sites, and greater fruit and vegetable intake was
associated with less decline at 1 hip site, in men. There were no
significant associations between baseline diet and subsequent bone loss
in women. CONCLUSION: These results support the hypothesis that
alkaline-producing dietary components, specifically, potassium,
magnesium, and fruit and vegetables, contribute to maintenance of BMD.
Calcium, phosphorus and magnesium intakes correlate with bone mineral content in postmenopausal women
Tranquilli AL, Lucino E, Garzetti GG, Romanini C.
Department of Obstetrics and Gynecology, University of Ancona, Italy.
Qualitative and quantitative differences in the dietary habits of
postmenopausal women were studied to assess their influence on bone
health and osteoporosis. A total of 194 postmenopausal women were
studied with forearm DEXA densitometry. 70 were osteoporotic and 124
served as controls. Women had been menopausal for 5-7 years, and had
never been treated with hormone replacement or drug therapy. A 3-day
dietary recall was completed on Sunday, Monday and Tuesday after the
examination: the results were processed by computer and daily calcium,
phosphorus and magnesium intakes were related to bone mineral content
(BMC). Data were compared with Student's t-test and significance was
assessed at p < 0.05. Regression analysis was performed to correlate
BMC and intake levels. The dietary intake of calcium, phosphorus and
magnesium was significantly reduced in osteoporotic women and
correlated with BMC. Calcium and magnesium intakes were lower than the
recommended daily allowance even in normal women. The results suggest
that nutritional factors are relevant to bone health in postmenopausal
women, and dietary supplementation may be indicated for the prophylaxis
of osteoporosis. Adequate nutritional recommendations and supplements
should be given before the menopause, and dietary evaluation should be
mandatory in treating postmenopausal osteoporosis.